Saliva Cancer
By knowing the advantages of saliva as a diagnostic fluid, in 1992, promoted the New York Academy of Sciences, a major conference to address this problem. The conference participants recommended the development of tests to measure more sensitive and specific, and to understand changes in the saliva by the therapy and drug abuse, endocrine function, systemic and oral diseases, genetic diseases, nutritional status, and changes due to age. The Conference was aware of the possible diagnosis of salivary research and successfully developed a saliva test is more sensitive and able to increase our understanding of the relationship between oral health to general health. Can disconnect developed a new technique, and analyze all the proteins found in human saliva, not only to be solved. This technique is called "three-step peptide fractionation '[three-step peptide fractionation] that can describe a protein marker of oral cancer and other diseases in the oral cavity. This method was developed by Timothy Griffin et al, at the American Society of Biochemistry and Molecular Biology.
They examined saliva samples from four cancer patients and found more than 1000 human proteins, including cancer-causing proteins. They also separate the proteins from more than 30 species of bacteria that have never been found in saliva, and some of them also have links to cancer.
Chih-Ming Ho, a professor and several colleagues at UCLA Microsystems Laboratories developed a sensor that can be detected with the biomarkers in saliva samples with oral cancer. The sensors have a micro chip that was programmed to bind to certain proteins associated, and will generate a fluorescent signal when the molecules bind to each other.
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