Saliva Cancer

Saliva Cancer

By knowing the advantages of saliva as a diagnostic fluid, in 1992, promoted the New York Academy of Sciences, a major conference to address this problem. The conference participants recommended the development of tests to measure more sensitive and specific, and to understand changes in the saliva by the therapy and drug abuse, endocrine function, systemic and oral diseases, genetic diseases, nutritional status, and changes due to age. The Conference was aware of the possible diagnosis of salivary research and successfully developed a saliva test is more sensitive and able to increase our understanding of the relationship between oral health to general health.
Can disconnect developed a new technique, and analyze all the proteins found in human saliva, not only to be solved. This technique is called "three-step peptide fractionation '[three-step peptide fractionation] that can describe a protein marker of oral cancer and other diseases in the oral cavity. This method was developed by Timothy Griffin et al, at the American Society of Biochemistry and Molecular Biology.
They examined saliva samples from four cancer patients and found more than 1000 human proteins, including cancer-causing proteins. They also separate the proteins from more than 30 species of bacteria that have never been found in saliva, and some of them also have links to cancer.
Chih-Ming Ho, a professor and several colleagues at UCLA Microsystems Laboratories developed a sensor that can be detected with the biomarkers in saliva samples with oral cancer. The sensors have a micro chip that was programmed to bind to certain proteins associated, and will generate a fluorescent signal when the molecules bind to each other.

They used 20 samples-10 saliva of healthy saliva, and saliva samples from 10 cancer patients, and the sensor is able to distinguish between each of the saliva from cancer patients and healthy individuals. Optical sensor in the device detects a protein IL-8 are higher than normal concentration in saliva, it is a marker for malignancy. Ultra-sensor protein is expressed can be used in the diagnosis of various diseases. Detection of clinical disease biomarkers with saliva is noninvasive and simple method, and an alternative analysis of blood, urine, or biopsy.

SUMMARY
Saliva is a complex liquid with various organic and inorganic elements, which together play a role in the oral cavity. Salivary glands glycoprotein plays an important role in the type and function of saliva. Been the interest in saliva as a diagnostic tool developed in recent years.
In the clinic and laboratory is relatively easy to obtain saliva in sufficient quantities for analysis, storage and shipping are also available with lower serum and urine analysis in comparison. For the patient will reduce under Technology, the non-invasive saliva anxiety and discomfort. However, few studies with saliva as a diagnostic fluid for oral cancer. Biochemical analysis of saliva has not been evaluated in clinical laboratories. Thus we can calculate, acidity and total protein sialat in patients with oral cavity cancer diagnostic methods to develop cost-effective and simple.