Since about 10 to 15 percent of adults worldwide suffer from periodontist at one time or another (1), oral health professionals are constantly challenged with treating patients for conditions that exist and help them prevent future events. Root planing, scaling, and in severe cases, surgical intervention is part of the standard treatment for periodontist, and antibiotics are used to control the infection.
However, in recent years, dental health professionals have honed in on the inflammation that accompanies periodontist. Research shows that inflammation in the mouth-particularly those associated with periodontists, may be a factor in chronic diseases like heart and vascular disease, diabetes, arthritis, Alzheimer's disease, complications of pregnancy, and a growing list of other conditions. The real culprit in inflammation is oxidation stress, disruption in the balance of oxidants and antioxidants. Oxidation stress is the result of excess production of free radicals, unstable molecules that attack the tissue cells to "steal" electrons from other molecules.
Although infections are the main triggers for inflammation and oxidation stress, there are many other causes, such as poor diet, alcohol consumption and use of nicotine or chemical pollutants. oxidation stress in the mouth can result from dental procedures and the materials used for whitening, composite fillings, implants, crowns, veneers, and so on. Antibiotics to control micro-organisms that contribute to periodontists and other infections, but they do not always cope with free radicals and oxidation stress that accompanies inflammation.
Innate defense through the saliva a natural antibiotic and antioxidant
The human body has an innate defense system that fight inflammation of the mouth: saliva. Saliva naturally contains antibacterial compounds that defend against bacteria and micro-organisms. Saliva also contains natural antioxidants that have been proven to neutralize free radicals contribute to oxidation stress and inflammation. Some recent scientific articles have explored salivary antioxidants and their role in oral health, including periodontal disease, OLP, and even cancer. (2,3,4,5) there is a growing consensus that local delivery of therapeutic agents (eg, antioxidants) into the oral cavity must be considered. (6)
Topical antioxidants to control inflammation
Many dental health professionals have begun to add natural antioxidants saliva with topical application of antioxidants. a suite of products, AO Pro Vantage, of Dallas-based Prescience, LL C (prescience.com), contain antioxidants, including phloretin and ferulic acid, which is applied directly to the gums. products are distributed through professional dental offices and are best used as part of a comprehensive oral health program. In the early 1990s, the compound Florentine and ferule acid is clinically proven to ward off free radicals that cause damage to skin cells. recently, scientists at Texas A & M University Baylor College of Dentistry has shown that the specific concentration and combination of phloretin and ferulic acid are very effective at neutralizing free radicals in the cells of the mouth caused by nicotine, alcohol, hydrogen peroxide and some of the The most common toxins that are introduced in the oral cavity. Additional studies showed that the combination of Florentine and ferule acid can actually increase cell proliferation and healing in oral cells. (7)
Treating periodontal disease will continue to depend on antibiotics for micro-organisms. And now, adding a natural antioxidant with topical antioxidants saliva in the mouth shows promise in reducing free radicals, oxidation stress and inflammation of the mouth. in the fight against periodontists and other oral inflammation, topical antioxidants take their place alongside antibiotics.
Reference
1. Brown, LJ, and Loe, H. Prevalence, extent, severity and progression of periodontal disease. Period-ontology 2000; 2, 57-71.
2. Sculley DV, ET Al. Salivary antioxidants and periodontal disease status, Proceedings of the Nutrition Society 2002; 6:137-143.
3. Battino M, ET Al. antioxidant capacity of saliva. Clinical Journal of Period-ontology 2002; 29:189-194.
4. Miricescu D, ET AL. antioxidant potential of saliva: clinical significance in oral diseases. Therapeutics, Pharmacology and Clinical Toxicology 2011; 15 2:1-5.
5. Gupta a, ET Al. Lipid per-oxidation and antioxidant status in head and neck squamous cell carcinoma patients. Oxidation Medicine and Cellular Longevity, April-June 2009.
6. Hershkovich O, ET Al. Age-related changes in salivary antioxidant profile: Possible implications for oral cancer. in the Journal of Gerontology 2007; 62A 4:361-366.
7. San Miguel SM, ET Al. A mixture of bio-active antioxidants promote fibroblast proliferation and migration in the human mouth. Archives Oral Biology 2011; DOI: 10.1015/jarchoralbil.2011.01.001.
Edward Allen, DDS, PhD, received his DDS from Baylor College of Dentistry in 1969. she completed her Residency in Periodontics and earned a PhD in Physiology from Baylor University Graduate School. Dr. Allen is Adjunct Professor in the Department of Periodontics at Baylor College of Dentistry and a full-time private practice in Dallas, Texas.
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